1. Guangye Li#, Guo Chen#, Guo-Hua Yuan#, Jia Wei#, Qingyang Ni, Jing Wu, Bei Yang, Li Yang*, Jia Chen*. Specific and efficient RNA A-to-I editing through cleavage of an ADAR inhibitor. Nat Biotechnol, 2025, doi: 10.1038/s41587-025-02591-2.

2. Yuhang Fan#, Wenchao Xu#, Bao-Qing Gao#, Huichao Qin, Xiaoyi Wu, Jia Wei, Qingyang Ni, Lina Zhou, Jiangchao Xiang, Jing Wu, Bei Yang, Li Yang, Jia Chen*. Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA. Nat Biotechnol, 2025, doi: 10.1038/s41587-025-02608-w.

3. Qimingxing Chen#, Yan Chang#, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen*, Jianfeng Li*. Targeted delivery of mRNA with polymer–lipid nanoparticles for in vivo base editing. ACS NANO, Feb 2025, 19(8): 7835–7850.

4. Wenyan Han#, Hou-Yuan Qiu#, Shangwu Sun#, Zhi-Can Fu#, Guo-Quan Wang#, Xiaowen Qian#, Lijie Wang, Xiaowen Zhai, Jia Wei, Yichuan Wang, Yi-Lin Guo, Guo-Hua Cao, Rui-Jin Ji, Yi-Zhou Zhang, Hongxia Ma, Hongsheng Wang, Mingli Zhao, Jing Wu, Lili Bi, Qiu-Bing Chen, Zifeng Li, Ling Yu, Xiaodun Mou, Hao Yin, Li Yang*, Jia Chen*, Bei Yang*, Ying Zhang*. Therapeutic base editing of the HBG promoter reactivates γ-globin expression with no detectable off-target mutations in beta-thalassemia HSCs. Cell Stem Cell, 2023, 30(12): 1624-1639.e8.

5. Wenyan Han#, Baoqing Gao#, Junjie Zhu#, Zongxing He#, Jianfeng Li*, Li Yang*, Jia Chen*. Design and application of the transformer base editor in mammalian cells and mice. Nat Protoc, 2023, 18(11): 3194-3228.

6. Wenwen Zhao#, Jifang Li#, Xiao Wang#, Wei Xu#, Baoqing Gao#, Jiangchao Xiang, Yaofeng Hou, Wei Liu, Jing Wu, Qilian Qi, Jia Wei, Xiaoyu Yang, Lu Lu*, Li Yang*, Jia Chen*, Bei Yang*. Prime editor-mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS-CoV-2variants. MedComm, 2023, 4: e356.

7. Xiaosa Li#*, Lina Zhou#, Bao-Qing Gao#, Guangye Li, Xiao Wang, Ying Wang, Jia Wei, Wenyan Han, Zixian Wang, Jifang Li, Runze Gao, Junjie Zhu, Wenchao Xu, Jing Wu, Bei Yang, Xiaodong Sun*, Li Yang*, Jia Chen*. Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure. Nat Commun, 2022, 13: 1669

8. Runze Gao#, Zhi-Can Fu#, Xiangyang Li#, Ying Wang#, Jia Wei, Guangye Li, Lijie Wang, Jing Wu, Xingxu Huang*, Li Yang*, and Jia Chen*. Genomic and transcriptomic analyses of prime editing guide RNA-independent off-target effects by prime editors. CRISPR J, 2022, 5(2): 276-293.

9. Jinlin Wang#, Zhou He#, Guoquan Wang#, Ruiwen Zhang#, Junyi Duan, Pan Gao, Xinlin Lei, Houyuan Qiu, Chuanping Zhang, Ying Zhang & Hao Yin*. Efficient targeted insertion of large DNA fragments without DNA donors. Nat Methods, 2022, 19(3): 331-340.

10. Xiang Gao#, Xu-Kai Ma#, Xiang Li, Guo-Wei Li, Chu-Xiao Liu, Jun Zhang, Ying Wang, Jia Wei, Jia Chen, Ling-Ling Chen & Li Yang*. Knockout of circRNAs by base editing back-splice sites of circularized exons. Genome Biol, 2022, 23: 16.

11. Lijie Wang#, Wei Xue#, Hongxia Zhang#, Runze Gao#, Houyuan Qiu#, Jia Wei, Lina Zhou, Yun-Ni Lei, Xiaocheng Wu, Xiao Li, Chengfang Liu, Jing Wu, Qiubing Chen, Hanhui Ma, Xingxu Huang, Cheguo Cai, Ying Zhang, Bei Yang*, Hao Yin*, Li Yang* & Jia Chen*. Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations. Nat Cell Biol, 2021, 23(5): 552-563.

12. Xiao Wang#, Chengfeng Ding#, Wenxia Yu#, Ying Wang#, Siting He#, Bei Yang#, Yi-Chun Xiong, Jia Wei, Jifang Li, Jiayi Liang, Zongyang Lu, Wei Zhu, Jing Wu, Zhi Zhou, Xingxu Huang, Zhen Liu*, Li Yang* & Jia Chen*. Cas12a Base editors induce efficient and specific editing with low DNA damage response. Cell Rep, 2020, 31(9): 107723.

13. Chun-Qing Song#, Tingting Jiang#, Michelle Richter, Luke H Rhym, Luke W Koblan, Maria Paz Zafra, Emma M Schatoff, Jordan L Doman, Yueying Cao, Lukas E Dow, Lihua Julie Zhu, Daniel G Anderson, David R Liu*, Hao Yin*, Wen Xue*. Adenine base editing in an adult mouse model of tyrosinaemia. Nat Biomed Eng, 2020, 4: 125-130.

14. Ying Wang#, Runze Gao#, Jing Wu#, Yi-Chun Xiong, Jia Wei, Sipin Zhang, Bei Yang, Jia Chen* and Li Yang*. Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs. Genome Biol, 2019, 20(1): 218.

15. Xiao Wang#, Jianan Li#, Ying Wang#, Bei Yang#, Jia Wei#, Jing Wu, Ruixuan Wang, Xingxu Huang*, Jia Chen* and Li Yang*. Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion. Nat Biotechnol, 2018, 36(10): 946-949.

16. Xiaosa Li#, Ying Wang#, Yajing Liu#, Bei Yang#, Xiao Wang, Jia Wei, Zongyang Lu, Yuxi Zhang, Jing Wu, Xingxu Huang*, Li Yang* and Jia Chen*. Base editing with a Cpf1-cytidine deaminase fusion. Nat Biotechnol, 2018, 36(4): 324-327.

17. Jian-Feng Xiang#, Qin Yang#, Chu-Xiao Liu#, Man Wu, Ling-Ling Chen*, Li Yang*. N(6)-Methyladenosines Modulate A-to-I RNA Editing. Mol Cell, 2018, 69(1): 126-135 e126.

18. Liqun Lei#, Hongquan Chen#, Wei Xue#, Bei Yang#, Bian Hu#, Jia Wei, Lijie Wang, Yiqiang Cui, Wei Li, Jianying Wang, Lei Yan, Wanjing Shang, Jimin Gao, Jiahao Sha, Min Zhuang, Xingxu Huang, Bin Shen*, Li Yang* and Jia Chen*. APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Nat Struct Mol Biol, 2018, 25(1): 45-52.

19. Hao Yin#, Chun-Qing Song#, Sneha Suresh, Suet-Yan Kwan, Qiongqiong Wu, Stephen Walsh, Junmei Ding, Roman L Bogorad, Lihua Julie Zhu, Scot A Wolfe, Victor Koteliansky, Wen Xue*, Robert Langer* & Daniel G Anderson*. Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Nat Chem Biol, 2018, 14(3): 311-316.

20. Lijie Wang#, Wei Xue#, Lei Yan#, Xiaosa Li, Jia Wei, Miaomiao Chen, Jing Wu, Bei Yang*, Li Yang* and Jia Chen*. Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor. Cell Res, 2017, 27(10): 1289-1292.

21. Hao Yin, Chun-Qing Song, Sneha Suresh, Qiongqiong Wu, Stephen Walsh, Luke Hyunsik Rhym, Esther Mintzer, Mehmet Fatih Bolukbasi, Lihua Julie Zhu, Kevin Kauffman, Haiwei Mou, Alicia Oberholzer, Junmei Ding, Suet-Yan Kwan, Roman L Bogorad, Timofei Zatsepin, Victor Koteliansky, Scot A Wolfe, Wen Xue, Robert Langer & Daniel G Anderson*. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Nat Biotechnol, 2017, 35(12): 1179-1187.

22. Hao Yin, Chun-Qing Song, Joseph R Dorkin, Lihua J Zhu, Yingxiang Li, Qiongqiong Wu, Angela Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet F Bolukbasi, Stephen Walsh, Roman L Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A Wolfe, Robert Langer, Wen Xue* & Daniel G Anderson*. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nat Biotechnol, 2016, 34(3): 328-33.

23. Xiao-Ou Zhang#, Hai-Bin Wang#, Yang Zhang, Xuhua Lu, Ling-Ling Chen*, and Li Yang*. Complementary sequence-mediated exon circularization. Cell, 2014, 159(1): 134-147.

24. Hao Yin#, Wen Xue#, Sidi Chen, Roman L Bogorad, Eric Benedetti, Markus Grompe, Victor Koteliansky, Phillip A Sharp, Tyler Jacks & Daniel G Anderson*. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat Biotechnol, 2014, 32(6): 551-553.

25. Wen Xue#, Sidi Chen#, Hao Yin#, Tuomas Tammela, Thales Papagiannakopoulos, Nikhil S. Joshi, Wenxin Cai, Gillian Yang, Roderick Bronson, Denise G. Crowley, Feng Zhang, Daniel G. Anderson, Phillip A. Sharp & Tyler Jacks*. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature, 2014, 514(7522): 380-384.

26. Jia Chen, Brendan F. Miller and Anthony V. Furano*. Repair of naturally occurring mismatches can induce mutations in flanking DNA. Elife, 2014, 3: e02001.

(#: co-first author, *: corresponding author)

1. Chengfang Liu#, Sifan Cheng#, Junjie Zhu, Lina Zhou, Jia Chen*. A quick guide to evaluating prime editing efficiency in mammalian cells. Methods in Enzymology, 2025, 712: 419-436

2. Jiangchao Xiang#, Wenchao Xu#, Jing Wu#, Yaxin Luo, Bei Yang*, Jia Chen*. Nucleoside deaminases: the key players in base editing toolkit. Biophys Rep, 2023, 9(6): 325-337.

3. Jin-Soo Kim*, Jia Chen*. Base editing of organellar DNA with programmable deaminases. Nat Rev Mol Cell Biol, 2024, 25(1): 34-45.

4. Li Yang*, Jia Chen*. Expanding genome editing scopes with artificial intelligence. Sci Bull, 2023, 68(23): 2881-2883.

5. Caixia Gao* & Jia Chen*. CRISPR adventures in China. CRISPR J, 2021, 4: 304-306

6. Qiubing Chen, Ying Zhang* and Hao Yin*. Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing. Adv Drug Deliv Rev, 2021, 168: 246-258.

7. Li Yang* & Jia Chen*. A tale of two moieties: rapidly evolving CRISPR/Cas-based genome editing. Trends Biochem Sci, 2020, 45: 874-888

8. Li Yang*, Bei Yang* and Jia Chen*. One prime for all editing. Cell, 2019, 179: 1448-1450

9. Jia Chen*, Bei Yang* and Li Yang*. To BE or not to BE, that is the question. Nat Biotechnol, 2019, 37: 520-522

10. Bei Yang*, Li Yang* and Jia Chen*. Development and application of base editors. CRISPR J, 2019, 2: 91-104

11. Hong-Xia Zhang, Ying Zhang* and Hao Yin*. Genome editing with mRNA encoding ZFN, TALEN, and Cas9. Mol Ther, 2019, 27(4): 735-746.

12. Hao Yin*, Wen Xue* and Daniel G. Anderson*. CRISPR-Cas: a tool for cancer research and therapeutics. Nat Rev Clin Oncol, 2019, 16(5): 281-295.

13. Jia Chen, Weizhi Ji, Prashant Mali and April Pawluk. The future of genome editing. Cell, 2018, 173: 1311-1313

14. Bei Yang*, Xiaosa Li, Liqun Lei and Jia Chen*. APOBEC: from mutator to editor. J Genet Genomics, 2017, 44: 423-437

15. Hao Yin, Kevin J. Kauffman and Daniel G. Anderson*. Delivery technologies for genome editing. Nat Rev Drug Discov, 2017, 16(6): 387-399.

16. Hao Yin, Rosemary L Kanasty, Ahmed A Eltoukhy, Arturo J Vegas, J Robert Dorkin and Daniel G Anderson*. Non-viral vectors for gene-based therapy. Nat Rev Genet, 2014, 15(8): 541-555.

(#: co-first author, *: corresponding author)